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People living with serious mental illness (SMI) are at higher risk for a wide range of chronic physical conditions, are more likely to visit the emergency department, be admitted to the hospital and have longer hospital stays compared to those without SMI. Nonadherence to drug treatments for major depressive disorder (MDD), schizophrenia and bipolar disorder is common. Several studies illustrate the problem, estimating that up to half of patients with bipolar disorder, MDD and/or schizophrenia do not take their medication as directed.

Otsuka and Lundbeck presented positive results from a Phase 3 clinical trial of brexpiprazole in the treatment of agitation in patients with Alzheimer's dementia at the 2022 Alzheimer's Association International Conference.

• Results from a Phase 3 clinical study for treatment of agitation in patients with Alzheimer’s dementia showed that patients treated with brexpiprazole had a statistically significantly greater reduction in agitation compared to placebo
• Agitation is a very prevalent clinical manifestation in Alzheimer’s dementia and one of the most complex and stressful aspects of care in patients affected by the disease. It is associated with greater caregiver burden, earlier nursing home placement, increased morbidity and mortality, and a substantial economic burden.
• Currently there are no FDA-approved pharmacological treatments for agitation in Alzheimer’s dementia

Otsuka has been recognized as a top workplace for disability inclusion by the Disability Equality Index® (DEI).

Otsuka Pharmaceutical Co., Ltd. and H. Lundbeck A/S announce positive results of the Phase 3 clinical trial of brexpiprazole in the treatment of agitation in patients with Alzheimer's dementia (NCT03548584). The analysis concluded that there is a statistically significant difference (p=0.0026) in the mean change from baseline to Week 12 in the Cohen-Mansfield Agitation Inventory (CMAI) total score between brexpiprazole and placebo.